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Find the best rental guesthouses in San Diego at Booking.com. The perfect guesthouse for rent is waiting in Pacific Beach, Gaslamp Quarter and Mission Valley. We have good availability and great rates so you can live like a local in a cozy guest home or a modern long stay room. Enjoy visiting SeaWorld San Diego, San Diego Convention Center and Downtown San Diego from your home away from home. Booking.com has the ideal rental guesthouses or self catering accommodations for your San Diego vacation.