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Rent the perfect San Francisco guesthouse at Booking.com. Find a cozy, spacious, or modern rental guesthouse in Fisherman's Wharf, Union Square and Downtown San Francisco to share with family and friends. Make yourself at home in our self catering guesthouses and plan trips to see Union Square, AT&T Park and Pier 39 Fisherman's Wharf. Booking.com has the best long stay guesthouses for rent in San Francisco with good availability and great rates.