This wasn't a problem for us, but the city of Oia is one of stairs - lots of them. If you have difficulty with going up and down stairs, this might be a difficult place to stay. Breakfast is good, not great, the dinner menu is much more impressive.
Service is impeccable and the locations is spectacular. We stayed for a week and never tired of the view or the city of Oia. We volunteered to stay at another hotel on one night in exchange for an upgraded room, dinner and massages. Although that hotel was newer and a little more modern with a private infiniti pool, we preferred Andronis Boutique and our fantastic hot tub. Amazing place to stay. I loved dinner at the restaurant.