The location is right off the Piazza di San Fracesco d'Assisi in Trastevere, just a few steps from Piazza Mastai, where taxis are plentiful, and (via tram) Piazza Venezia and Trastevere train station are a few minutes away. Wonderful, clean, spacious rooms, strong WiFi, and great breakfast room, where you are likely to chat with interesting people from around the world. The owner, Alessandra, though, makes this an exceptional place to stay. She is extremely knowledgeable and friendly, and is ready, willing and able to help guests to experience Rome in the ways they would like.
Just to know - depending on your arrival time, you may have to call or text to have someone meet you there with your key.
Also, if you arrange your own taxi, it is essentially at the corner of Via dei Marescotti and Piazza di San Francesco, and access is much easier through the Piazza than it would be trying to navigate the street itself. San Francesco a Ripa is a landmark all taxi drivers will know.