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Park outside of the Quarter and take a cab. Parking and traffic is terrible. If you can get past the traffic experience, go to Pat O'Brien's and have fun. Eat at Broussard's and check out the French Pastries at Croissant D'Or. Wear comfortable shoes and clothing. Take a bottle of water with you if you plan to walk around. Check out the architecture of the buildings and view the gardens and patios on the upper Quarter.
Stay away from Bourbon Street at night unless you want a totally disgusting drunk degenerate experience (in which case it is truly incomparable, thank God!), but the rest of the French Quarter is fabulous. I recommend Irene's Cuisine among the many fabulous restaurants of the Quarter.
Historic, music on every corner. Royal Street is great for galleries and antiques, while Bourbon street is where you can party 24/7. Frenchman Street is where you want to be for great music. Make sure to stop by Cafe du Monde for a cafe au lait and beignets in the morning!
City and state need to work on sidewalk and street safety. Conditions are horrible with holes and missing bricks with no warnings. Not handicap accessible People are the cities greatest asset! Food and culture great too
Always music somewhere. We enjoyed the House of Blues Friday afternoon band in the Voodoo Garden. There was so much boiled shrimp in one order it would have fed both of us. It was $15.95 an order. I'd suggest getting one order then see if you need more.
Stay at the St. Phillips Hotel. You can walk everywhere in the French Quarter and close to Bourbon St but far enough away so you can sleep at night. The French Market, the Garden District, shops, trolley ride, and Doris's Restaurant are a must.